A significant shift is occurring as major Bitcoin holders increase their reserves, with inflows continuing into U.S. spot Bitcoin ETFs. According to data from Santiment on September 23, wallets holding between 100 to 1,000 BTC have added a total of 113,950 BTC since July 15. This accumulation marks a 2.22% rise in their holdings, bringing the total to approximately 5.24 million BTC.